用途 Nω-硝基-L-精氨酸已被用于： 作为一氧化氮合成酶 (NOS) 抑制剂，用于测量细胞色素C还原检测中一氧化氮（NO）衍生物的释放量；收缩研究用纤维束的预处理；作为 NOS 抑制剂表征云南红豆杉 细胞中NO的生成；作为神经元一氧化氮合成酶 (nNOS) 的不可逆抑制剂对浮囊制剂作进行预先温育处理 Nω-Nitro-L-arginine displays potent inhibition of NOS with selectivity for NOS1 and NOS3 over NOS2. It has been observed to inhibit endothelial nitric oxide biosynthesis and decrease radical generation of peroxynitrite ions. Other inhibitory effects demonstrated in experiments include blocking brady-kinin-induced relaxation in dog coronary artery strips and suppressing morphine tolerance in mice. N G-Nitro-L-arginine causes significant vasoconstriction and is utilized in studying nitric oxide as a neuronal messenger. Application Nω-Nitro-L-arginine has been used:as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay to pretreat fiber bundles for contractile studies；as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells；as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations.
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Nω-Nitro-L-arginine
Dangerous GoodsCAS number：2149-70-4 molecular formula：C6H13N5O4
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Specs
| Chinese alias | - | ||
| English alias | NCGC00024716-09 | Spectrum3_001083 | Arginine, omega-nitro-, L- | KBio1_001016 | Q7041453 | SR-01000597670 | N(sup G)-Nitro-L-arginine | N-Nitro-L-arginine | (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid | EN300-204408 | hDDAH inhibito | ||
| CAS number | 2149-70-4 | molecular formula | C6H13N5O4 |
| molecular weight | 219.2 g/mol | Exact mass | - |
| PSA | 160.000 Ų | logp | -3.6 |
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Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
RM2982100
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