TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies. TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies. product description： 4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.
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4-Hydroxy-TEMPO
Dangerous GoodsCAS number：2226-96-2 molecular formula：C9H18NO2
overview
compound introduction
Specs
| Chinese alias | 4-羟基-TEMPO 自由基 | 哌啶醇氧化物 | TEMPOL 自由基 | 4-羟基-2,2,6,6-四甲基哌啶1-氧基 自由基 | ||
| English alias | 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical | 4-Hydroxy-TEMPO Free Radical | TEMPOL Free Radical | ||
| CAS number | 2226-96-2 | molecular formula | C9H18NO2 |
| molecular weight | 172.24 g/mol | Exact mass | ≥98% |
| PSA | 24.500 Ų | logp | 0.900 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany：
1
Personal protective equipment：
dust mask type N95 (US),Eyeshields,Gloves
RTECS：
TN8991000
Production methods and uses
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upstream information
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downstream information
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MSDS
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