L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine .Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication. L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine .Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication. An irreversible inhibitor of 3-ketodihydrosphingosine synthetase
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L-Cycloserine
CAS number：339-72-0 molecular formula：C3H6N2O2
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| Chinese alias | - | ||
| English alias | (-)-4-amino-3-isoxazolidinone | Levcicloserina [INN-Spanish] | LEVCYCLOSERINE [INN] | L-Oxamicina [Italian] | BSPBio_001132 | MFCD00064324 | 4AX | Prestwick1_001086 | (4S)-4-amino-1,2-oxazolidin-3-one | HMS3264E06 | LP00199 | NCGC00093674-01 | NCGC0009367 | ||
| CAS number | 339-72-0 | molecular formula | C3H6N2O2 |
| molecular weight | 102.09 g/mol | Exact mass | - |
| PSA | 64.400 Ų | logp | -1.500 |
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