compound introduction
Ispinesib (SB-715992)是高亲和性的KSP(HsEg5)特异性抑制剂，Ki为1.7 nM。An allosteric, specific reversible inhibitor of Eg5 Ispinesib (SB-715992, CK0238273)是一种有效的，特异性的，可逆kinesin spindle protein (KSP)抑制剂，无细胞试验中Kiapp为1.7 nM，对CENP-E， RabK6， MCAK， MKLP1，KHC和Kif1A没有抑制作用。Ispinesib可诱导有丝分裂阻滞和细胞的凋亡. Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. An allosteric, specific reversible inhibitor of Eg5
