8-（4-氯苯硫基）鸟苷3'，5'-环一磷酸钠盐（8-CPT-2'-O-Me-cAMP•Na）是cGKIα，cGKIβ和cGKII（cGMP-依赖性蛋白激酶（PKG）Iα，Iβ和II型）以及CNG（cGMP门控离子通道）。与cGMP相比，该化合物具有更高的活化潜能，并保留了出色的细胞膜通透性和磷酸二酯酶稳定性。8-CPT-2'-O-Me-cAMP•Na已被推荐为不合适的类似物（如二丁酰-cGMP）的优选替代物。 产品应用： 8-（4-氯苯硫基）-鸟苷 3′,5‘-环状单磷酸钠盐已被用于激活血管平滑肌细胞（VSMC）中的GMP依赖性蛋白激酶（PKG）。 8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt (8-CPT-2'-O-Me-cAMP? Na ) is a selective activator of cGKI α, cGKI β, and cGKII (cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II )as well as of CNG (cGMP-gated ion channels). The compounds higher activation potential as compared to cGMP, and retains excellent cell membrane permeability and phosphodiesterase stability. 8-CPT-2'-O-Me-cAMP ? Na has been preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
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8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt
Dangerous GoodsCAS number：51239-26-0 molecular formula：C16H14ClN5NaO7PS
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| Chinese alias | - | ||
| English alias | sodium 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate | 8-(4-chlorophenylthio)-3',5'-cyclic GMP.Na | 8-pCPT-cGMP.Na | sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-1,6-dihydro-9H-purin-9-yl}-7-hydroxy-2-oxotetrahydro-2H, | ||
| CAS number | 51239-26-0 | molecular formula | C16H14ClN5NaO7PS |
| molecular weight | 509.79 g/mol | Exact mass | ≥95%(HPLC) |
| PSA | - | logp | - |
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WGK Germany：
3
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