Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).A highly potent and selective serotonin (5-HT) uptake inhibitor Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6). A highly potent and selective serotonin (5-HT) uptake inhibitor
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Paroxetine hydrochloride hemihydrate
Dangerous GoodsCAS number：110429-35-1 molecular formula：C19H20FNO3·HCl·1/2 H2O
overview
compound introduction
Specs
| Chinese alias | 盐酸帕罗西汀半水合物 | ||
| English alias | PAROXETINE HYDROCHLORIDE [VANDF] | UNII-X2ELS050D8 | KS-1094 | Paroxetine Hydrochloride Hemihydrate 1.0 mg/ml in Methanol (as anhydrous free base) | PAROXETINE HCL HEMIHYDRATE | PAROXETINE HYDROCHLORIDE HEMIHYDRATE [MI] | PAROXETINE HYDROCHLORIDE HEMIHYDR | ||
| CAS number | 110429-35-1 | molecular formula | C19H20FNO3·HCl·1/2 H2O |
| molecular weight | 374.83 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 80.400 Ų | logp | 3.5 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H411: 对水生生物有毒并具有长期持续影响 H302: 吞食有害 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US)， Eyeshields， Gloves
RTECS：
TM4569320
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
110429-35-1 | Paroxetine Hydrochloride.pdf
