compound introduction
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂，其 IC50 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路，也能抑制 RET 诱导的 ERα 磷酸化。
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SPP 86
Dangerous GoodsCAS number：1357349-91-7 molecular formula：C16H15N5
overview
Specs
| Chinese alias | 1-(1-甲基乙基)-3-(2-苯基乙炔基)-1H-吡唑并[3,4-d]嘧啶-4-胺 | ||
| English alias | SPP8 | 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | SPP86 | ||
| CAS number | 1357349-91-7 | molecular formula | C16H15N5 |
| molecular weight | 277.32 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 69.600 Ų | logp | 2.6 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口
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MSDS
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