compound introduction
PD180970 是一种高效且具有 ATP 竞争性的 p210Bcr-Abl 激酶抑制剂，可抑制 p210Bcr-Abl 的自磷酸化，IC50 为 5 nM。PD180970 还抑制 Src 和 KIT 激酶，IC50 分别为 0.8 nM 和 50 nM。PD180970 可诱导 K562 白血病细胞凋亡 (apoptosis)，可用于慢性粒细胞白血病的研究。 Product description： PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research.
