金丝桃素二环己基铵盐是从贯叶连翘中分离得到的天然产物金丝桃素的二环己基铵盐制剂。金丝桃素抑制单胺类神经递质血清素、多巴胺、去甲肾上腺素和GABA的摄取。抑制血清素摄取的具体机制与高福林诱导的细胞内钠离子水平升高有关。AMPA诱导的电流被金丝桃素竞争性和不完全抑制，而NMDA受体激活的离子电导被完全和不竞争性抑制。金丝桃素具有神经保护作用，可诱导β-淀粉样蛋白聚集体解体，改善空间记忆，减少星形胶质细胞增生和小胶质细胞活化。诱导型一氧化氮合酶（iNOS）的作用受到金丝桃素的调控，表明通过抑制iNOS在mRNA Hyperforin dicyclohexylammonium salt is the dicyclohexylammonium salt preparation of the natural product Hyperforin isolated from|Hypericum perforatum|. Hyperforin inhibits the uptake of the monoamine neurotransmitters serotonin, dopamine, noradrenaline, and GABA. The specific mechanism of serotonin uptake inhibition is correlated with Hyperforin-induced elevation of intracellular Na|+|levels. AMPA induced currents were shown to be competitively and incompletely inhibited by Hyperforin, while NMDA receptor-activated ionic conductance was completely and uncompetitively inhibited. Hyperforin is described to present neuroprotective effects, demonstrating the induction of amyloid-beta aggregate disassembly, improvement of spatial memory, and decrease of astrogliosis and microglia activation. The action of inducible nitric oxide synthase (iNOS) was modulated by Hyperforin, demonstrating reduced NO production through suppression of iNOS on the mRNA and protein levels, further correlating to the neuroprotection generated by this compound. Hyperforin demonstrates selective activation of the transient receptor potential channel 6. Activation of the PXR (pregnane X receptor) by Hyperforin produces induction of cytochrome p450 3A4 monooxygenase expression, promoting oxidation metabolism activity of this enzyme. Hyperforin dicyclohexylammonium salt is an activator of TRPC6.
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Hyperforin dicyclohexylammonium salt
Dangerous GoodsCAS number：238074-03-8 molecular formula：C35H52O4•(C12H23N)
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | HY-116330A | DTXSID30677360 | Hyperforin (dicyclohexylammonium) salt | (1R,5R,7S,8R)-4-Hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione--N-cyclohexylcyclohexanamine (1/1) | ||
| CAS number | 238074-03-8 | molecular formula | C35H52O4•(C12H23N) |
| molecular weight | 536.7818132 g/mol | Exact mass | ≥97% |
| PSA | 83.500 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H314: 造成严重的皮肤灼伤和眼睛损伤 H302: 吞食有害 H318: 造成严重的眼睛损伤 H400: 对水生生物有剧毒
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P363: 再次使用之前，请清
WGK Germany：
3
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
238074-03-8 | Hyperforin (stable Dicyclohexylammoniumsalt).pdf
