Information GS967 GS967 (GS458967) is a potent and selective inhibitor of late I Na with anti-arrhythmic actions. Targets late INa 0.13 μM In vitro GS967 (3 μM) has no significant effect on L- or T-type calcium channel currents or Na+-Ca2+ exchanger current (INCX), and 1 μM GS967 has minimal or no effect on the ATP-inhibited K+ current or on human cardiac ion channels expressed in human embryonic kidney 293 or Chinese hamster ovary cells. GS967 is a novel sodium channel modulatorspecifically developed to inhibit persistent sodium current, with a 42-fold preference for persistent as opposed to peakcurrent inhibition. In vivo GS967 protects against seizures and prematurelethality in vivo. Chronic GS967 does not cause overt behavioraltoxicity or sedation in wild-type mice at theeffective anticonvulsant dose. GS967 suppresses arrhythmogenicity evoked by ischemia, hypokalemia, and catecholamines in canine and porcine models.
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GS967
Dangerous GoodsCAS number：1262618-39-2 molecular formula：C14H7F6N3O
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | GS4589671,2,4-Triazolo[4,3-a]pyridine,6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)- | ||
| CAS number | 1262618-39-2 | molecular formula | C14H7F6N3O |
| molecular weight | 347.22 g/mol | Exact mass | - |
| PSA | 39.400 Ų | logp | 5.307 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H320: 引起眼睛刺激
Statement of Preventive Measures：
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。
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