compound introduction
BTB06584 是一种选择性的且依赖 IF1 的线粒体 F1Fo-ATPase 抑制剂，且不影响 ATP 的合成。BTB06584 可延迟缺血性细胞死亡。 Information BTB06584 BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase . Targets F1 Fo-ATPase In vitro BTB06584 IF1-dependently inhibits F1 Fo-ATPase activity with no effect on without compromising ATP synthesis, and also limits ischemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATP synthase. In vivo BTB06584 rescues the defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants without causing significant toxicity.
