compound introduction
Fisogatinib (BLU-554)是一种有效的、高度选择性的、具有口服活性的FGFR4抑制剂，IC50为5 nM。对FGFR1-3的IC50范围为624-2203 nM。 Information Fisogatinib (BLU-554) Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM. Targets FGFR4 (Cell-free assay) 5 nM In vitro BLU-554 exploits a unique interaction with FGFR4 to confer potency and selectivity In vivo BLU-554 is well tolerated in these tumor models. Administration of BLU-554 induces tumor regression in liver cancer models.
