CAS number：920509-32-6 molecular formula：C17H12Cl2N6O4
Resmetirom (MGL-3196,)是一种肝定向、具有口服活性、选择性的thyroid hormone receptor β(THR-β)激动剂，EC50为0.21μM，对THR-β的选择性是THR-α的28倍。 Information Resmetirom (MGL-3196) Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay. Targets THR-β (Cell-free assay) 0.21μM(EC50)
| Chinese alias | 瑞美替尼 (MGL-3196) | ||
| English alias | (S)-(-)-SEGPHOS(regR) | Resmetirom | MGL-3196 | compound 53 [PMID: 24712661] | SY289460 | WHO 10850 | VLB50932 | 2-[3,5-Dichloro-4-[(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy]phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | s6663 | ||
| CAS number | 920509-32-6 | molecular formula | C17H12Cl2N6O4 |
| molecular weight | 435.22 g/mol | Exact mass | - |
| PSA | 136.000 Ų | logp | 3.021 |
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