Lycorine 是从石蒜科植物中提取的天然生物碱。Lycorine 是强效的 SCAP 抑制剂，Kd 值 15.24 nM。Lycorine 下调 SCAP 蛋白水平而不改变其转录。Lycorine 也是黑色素瘤血管生成抑制剂。Lycorine 有潜力用于前列腺癌和代谢疾病的研究。 Information Lycorine Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis . In vitro Lycorine can inhibit protein synthesis in eukaryotic cells and acetylcholinesterase activity. Lycorine could effectively arrest the cell cycle at the G2/M phase and induce apoptosis in HL-60 cells. It is able to block the KM3 cell cycle at G0/G1 phase through the down-regulation of both cyclin D1 and CDK4. In vivo Lycorine, when tested in the human leukemia xenograft models, appears to exhibit anti-tumor activity in vivo. It prolongs the mean survival time of SCID leukemia xenograft models. Lycorine could alleviate the infiltration of tumor cells into tissues. Cell Research(from reference) Concentrations：0, 0.5, 1, 5, and 10 μM Incubation Time：24, 48, 72, and 96 h
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Lycorine
Dangerous GoodsCAS number：476-28-8 molecular formula：C16H17NO4
overview
compound introduction
Specs
| Chinese alias | 番石榴碱 | (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-六氢-1H-[1,3]二氧戊环并[4,5-j]吡咯并[3,2,1-de]菲啶-1,2-二醇 | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14-羟基-85,14-二甲氧基-33,2,7,10-四甲基-12,6-二氧代-7-氮杂-1(6,4)-恶嗪烷-3(2,3)-环氧乙烷8(1,3)-苯并氮杂环十四烷-10,12-二烯-4-基 N-(6-(2,5-二氧代-2,5-二氢-1H-吡咯-1- | ||
| English alias | Bunt-no-more | Bio2_000502 | EINECS 207-503-6 | Ethyl o-hydroxybenzoate | U-17312E | KBio2_000022 | HMS1791B04 | KBioGR_000022 | KBioSS_000022 | MFCD00221746 | (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.0?,??.0?,?.0??,??]nonadeca-2,4(8),9,15-tetra | ||
| CAS number | 476-28-8 | molecular formula | C16H17NO4 |
| molecular weight | 287.31 g/mol | Exact mass | ≥98% |
| PSA | 62.200 Ų | logp | 0.713 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
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MSDS
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