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AZD5363

Dangerous Goods

CAS number：1143532-39-1    molecular formula：C21H25ClN6O2

overview
Specs
numbering system
physicochemical properties
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overview

compound introduction

AZD5363是各种AKT亚型抑制剂，IC50 Capivasertib (AZD5363)有效抑制Akt(Akt1/Akt2/3)的所有亚型，在无细胞试验中IC50为3 nM/8 nM/8 nM，对P70S6K/PKA也具有相似的抑制效果，而对ROCK1/2抑制活性较低。Phase 2。 AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2.

Specs

Chinese alias-
English aliasAZC5363 | DB12218 | J-514447 | s8019 | NCGC00345795-04 | 4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidine-4-carboxamide | Capivasertib (AZD5363) | Trifluoromethane, refrigerated liquid [UN3136] [Nonflammable ga
CAS number1143532-39-1molecular formulaC21H25ClN6O2
molecular weight428.92 g/molExact mass-
PSA120.000 Ųlogp1.7

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS08 , GHS07
Signal word：
Warning
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害 H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。

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