2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione

Dangerous Goods

CAS number：5054-59-1 molecular formula：C13H10N2O5

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Thalidomide-4-OH (Cereblon ligand 2) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-4-OH (Cereblon ligand 2) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。 Thalidomide-OH (Cereblon ligand 2, E3 ligase Ligand 2) is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs.

Specs

Chinese alias	-
English alias	SY233142 \| 4-hydroxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione \| US11059801, Compound D-1 \| ZKA69498 \| 2-(2,6-dioxo-piperidine-3-yl)-4-hydroxy-isoindole-1,3-dione \| 4-Hydroxy thalidomide, (+/-)- \| SKEXQIJIXQSFRX-UHFFFAOYSA-N \| XMPJICVFSDYOEG-UHFFFAO
CAS number	5054-59-1	molecular formula	C13H10N2O5
molecular weight	274.23 g/mol	Exact mass	≥95%
PSA	104.000 Å²	logp	0.500

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS07

Signal word：

Warning

Hazard Statement：

H302: 吞食有害 H361: 怀疑破坏生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。