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JH-II-127

Dangerous Goods

CAS number:1700693-08-8    molecular formula:C19H21ClN6O3

overview

compound introduction

在室温下运输。储存在室温下。 Shipped at Room Temperature. Store at Room Temperature. JH-II-127 is a potent, selective and brain-penetrant inhibitor of LRRK2 with IC50 of 6.6 nM, 2.2 nM and 47.7 nM for LRRK2-wild-type, LRRK2-G2019S and LRRK2-A2016T, respectively.

Specs

Chinese alias[4-[[5-氯-4-(甲基氨基)-7H-吡咯并[2,3-d]嘧啶-2-基]氨基]-3-甲氧基苯基]-吗啉-4-基甲酮
English alias[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone | [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinylmethanone
CAS number1700693-08-8molecular formulaC19H21ClN6O3
molecular weight416.87 g/molExact mass≥98%
PSA104.000 Ųlogp2.5

numbering system

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physicochemical properties

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Safety information

pictogram:
GHS07
Signal word:
Warning
Hazard Statement:
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

Production methods and uses

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upstream information

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downstream information

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MSDS

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