compound introduction
Losmapimod (GW856553X, GW856553, GSK-AHAB)是有效的选择性p38 MAPK抑制剂，其作用于p38α和p38β的pKi分别为8.1 和 7.6。P38 MAPKs涉及细胞分化、凋亡和自噬。Phase 3。
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Losmapimod
Dangerous GoodsCAS number：585543-15-3 molecular formula：C22H26FN3O2
overview
Specs
| Chinese alias | 洛斯马匹莫德 | ||
| English alias | GS856553 | NSC785336 | NSC-785336 | HY-10402 | MFCD16619322 | F2DQF16BXE | GTPL7835 | BCP09909 | NSC800785 | NSC-800785 | SB68608 | 6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-N-neopentylnicotinamide | 6-(5-cyclopropylcarbamoyl-3-fluoro-2-methyl- | ||
| CAS number | 585543-15-3 | molecular formula | C22H26FN3O2 |
| molecular weight | 383.46 g/mol | Exact mass | - |
| PSA | 71.100 Ų | logp | 3.8 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
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MSDS
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