Afatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM. Afatinib is a potent inhibitor of EGFR phosphorylation. Afatinib showed positive results in assays against a variety of human cancer cell lines, including A431, murine NIH-3T3 cells, and breast cancer cell line BT-474.An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation Afatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM. Afatinib is a potent inhibitor of EGFR phosphorylation. Afatinib showed positive results in assays against a variety of human cancer cell lines, including A431, murine NIH-3T3 cells, and breast cancer cell line BT-474. An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation
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Afatinib
Dangerous GoodsCAS number：439081-18-2 molecular formula：C24H25ClFN5O3
overview
compound introduction
Specs
| Chinese alias | 阿法替尼 | ||
| English alias | BIBW2992 | (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide | AFATINIB [MI] | AKOS001015518 | BIBW2992 - Afatinib | NSC799327 | NSC-799327 | 850140-72-6 (free base) | Afatinib [USAN:INN] | EX- | ||
| CAS number | 439081-18-2 | molecular formula | C24H25ClFN5O3 |
| molecular weight | 485.94 g/mol | Exact mass | ≥95% |
| PSA | 88.600 Ų | logp | 3.600 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS09 , GHS07
Signal word：
Danger
Hazard Statement：
H319: 引起严重眼睛刺激 H301: 吞咽会中毒 H410: 对水生生物有剧毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P263
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