Spautin-1

Dangerous Goods

CAS number：1262888-28-7 molecular formula：C15H11F2N3

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Spautin-1是一种特异性和有效的自噬抑制剂，可抑制泛素特异性肽酶USP10和 USP13，IC50s 约为0.6-0.7 μM。 Product Application： Spautin-1 has been used as an autophagy inhibitor: to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model; to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin; to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay.

Specs

Chinese alias	6-氟-N-[(4-氟苯基)甲基]-4-喹唑啉胺 \| 6-氟-N-(4-氟苄基)喹唑啉-4-胺
English alias	A889470 \| CS1815 \| MBCQ derivative C43 \| NCGC00263555-05 \| deoxy-ATP, 2'-deoxyadenosine triphosphate, Deoxyadenosine 5'-triphosphate \| EN300-93027 \| P2613 \| Spautin-1 \| CCG-267171 \| 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine \| HMS3871D13 \| EN300-172107
CAS number	1262888-28-7	molecular formula	C15H11F2N3
molecular weight	271.26 g/mol	Exact mass	≥98%(HPLC)
PSA	37.800 Å²	logp	3.600

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS05 , GHS07

Signal word：

Danger

Hazard Statement：

H302: 吞食有害 H318: 造成严重的眼睛损伤

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。

WGK Germany：