BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A. BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
N,N,2-Trimethyl-5-nitrobenzenesulfonamide
Dangerous GoodsCAS number：433695-36-4 molecular formula：C9H12N2O4S
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 433695-36-4 | BRL-50481 | BRL 50481 | N,N,2-trimethyl-5-nitrobenzenesulfonamide | 5-Nitro-2,N,N-trimethylbenzenesulfonamide | N,N,2-Trimethyl-5-nitro-benzenesulfonamide | Benzenesulfonamide, N,N,2-trimethyl-5-nitro- | BRL50481 | CHEMBL484928 | N,N,2-trime | ||
| CAS number | 433695-36-4 | molecular formula | C9H12N2O4S |
| molecular weight | 244.27 g/mol | Exact mass | - |
| PSA | 91.600 Ų | logp | 1.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
