NSC697923

Dangerous Goods

CAS number：343351-67-7 molecular formula：C11H9NO5S

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

NSC697923 是一种有效的 UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) 抑制剂。NSC697923 通过促进 p53 野生型神经母细胞瘤细胞中 p53 的核输入而诱导神经母细胞瘤细胞死亡。NSC697923 通过激活 JNK 介导的凋亡途径诱导 p53 突变神经母细胞瘤细胞死亡。NSC697923 抑制 DNA 损伤和 NF-κB 信号传导。具有抗肿瘤活性。 Product description NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity. Product Application NSC697923 has been used as an inhibitor in STING-dependent NF-κB (nuclear factor-κB) activation after DNA damage, mediated by TRAF6 (TNF receptor-associated factor 6)

Specs

Chinese alias	2-(4-甲基苯基)磺酰基-5-硝基呋喃
English alias	AM20210010 \| Furan,2-[(4-methylphenyl)sulfonyl]-5-nitro- \| Q27463656 \| EN300-115577 \| SCHEMBL15200927 \| BS-16607 \| HY-13811 \| NSC697923 \| NSC-697923 \| s7142 \| D83608 \| Furan, 2-[(4-methylphenyl)sulfonyl]-5-nitro- \| SW220082-1 \| A14068 \| 2-Nitro-5-p-toluen
CAS number	343351-67-7	molecular formula	C11H9NO5S
molecular weight	267.26 g/mol	Exact mass	10mM in DMSO
PSA	101.000 Å²	logp	2.600

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS05 , GHS07

Signal word：

Danger

Hazard Statement：

H302: 吞食有害 H318: 造成严重的眼睛损伤

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。