ACA是一种广谱磷脂酶 A2 (PLA2) 的抑制剂，TRP channel的阻滞剂。ACA 也是一种有效的钙离子激活氯通道 (calcium-activated chloride channels) 的可逆抑制剂，有潜力用于心律失常的相关研究。 ACA通过抑制人血小板中的磷脂酶A2（PLA2）来抑制肾上腺素刺激的血栓烷生成。还阻断胰岛中葡萄糖诱导的胰岛素分泌。具有中等程度的白三烯拮抗剂活性。 ACA可阻断肾上腺素刺激的血小板中血栓烷的产生。抑制肺泡II型细胞中ATP刺激的磷脂酰胆碱（PC）分泌。还可以阻断佛波酯和A23187诱导的II型细胞中PC的分泌。据报道可阻断胰腺β细胞中葡萄糖诱导的胰岛素分泌。表现出中等程度的白三烯拮抗剂活性。 N-(p-Amylcinnamoyl) anthranilic Acid (ACA), a cell permeable inhibitor of PLA2, has been reported to inhibit α-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion. Additionally, by inhibiting PLA2, ACA consequentially suppresses glucose-induced arachidonic acid formation in cells. Furthermore, research has shown ACA to modulate the activity of different transient receptor potential channels. In particular, ACA's blocking ability of diacylglycerol-activated TRP channels is of special interest since it offers the opportunity to interfere with receptor-induced Ca2+-dependent signaling processes in vascular smooth muscle cells and platelets.
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N-(p-Amylcinnamoyl)anthranilic acid
Dangerous GoodsCAS number：110683-10-8 molecular formula：C21H23NO3
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Specs
| Chinese alias | - | ||
| English alias | ACA - CAS 110683-10-8 | N-(4-Pentylcinnamoyl)anthranilic acid | N17081 | BRD-K77817104-001-01-3 | Benzoic acid, 2-((1-oxo-3-(4-pentylphenyl)-2-propenyl)amino)- | 2-(3-(4-Pentylphenyl)acrylamido)benzoic acid | Benzoic acid, 2-((1-oxo-3-(4-pentylphenyl)-2-p | ||
| CAS number | 110683-10-8 | molecular formula | C21H23NO3 |
| molecular weight | 337.4 g/mol | Exact mass | - |
| PSA | 66.400 Ų | logp | 6.4 |
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Safety information
pictogram：
GHS09
Signal word：
Warning
Hazard Statement：
H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
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