CAS number：1422955-31-4 molecular formula：C12H6ClFN4O3
TC-S 7009 是一种有效的选择性 HIF-2α 抑制剂，Kd 为 81 nM。TC-S 7009 对 HIF-2α 的选择性高于 HIF-1α (Kd ≫ 5 μM)。HIF-2α-IN-3 能破坏 HIF-2α 异二聚体，降低 DNA 结合活性，并降低 HIF-2α 靶基因的表达。 Product description TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression.
| Chinese alias | N-(3-氯-5-氟苯基)-4-硝基-2,1,3-苯并恶二唑-5-胺 | ||
| English alias | MS-24479 | AKOS040742689 | Q27451504 | HIF-2 inhibitor 2 | TC-S 7009 | 4ghi | HIF-2 ANTAGONIST 2 | 2,1,3-Benzoxadiazol-5-aMine,N-(3-chloro-5-fluorophenyl)-4-nitro- | N-(3-Chloro-5-Fluorophenyl)-4-Nitro-2,1,3-Benzoxadiazol-5-Amine | E99008 | CDQUJZKBRAFWNG | ||
| CAS number | 1422955-31-4 | molecular formula | C12H6ClFN4O3 |
| molecular weight | 308.65 g/mol | Exact mass | ≥99%(HPLC) |
| PSA | 96.800 Ų | logp | 3.8 |
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