CAS number：916232-21-8 molecular formula：C28H19FN2O4
GS143 是一种选择性的 IκBα 泛素化抑制剂，对于 SCFβTrCP1 介导的 IκBα 泛素化作用的 IC50 为 5.2 μM。GS143 抑制靶基因的 NF-κB 活化和转录，并且不抑制蛋白酶体的活性，并具有抗哮喘作用。 GS143 is a selective inhibitor of IκBα ubiquitination with IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes. GS143 exhibits anti-asthma effect.
| Chinese alias | 4-[4-[[5-(2-氟苯基)-2-呋喃基]亚甲基] -4,5-二氢-5-氧代-3-(苯甲基)-1H-吡唑-1-基]苯甲酸 | ||
| English alias | 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid | ||
| CAS number | 916232-21-8 | molecular formula | C28H19FN2O4 |
| molecular weight | 466.46 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 83.100 Ų | logp | 5.4 |
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