compound introduction
AUDA是可溶性环氧化物水解酶的抑制剂（sEH，小鼠的IC | 50 | = 18 nM）。AUDA已显示出降压作用，并伴有尿环氧化物与二醇的比率增加。在浓度为10μM时，AUDA能够将过氧化物酶体增殖物激活的受体α（PPARα）激活3倍，而对PPARδ或PPARγ无影响。 AUDA (compound 43) 是一种有效的 soluble epoxide hydrolase (sEH) 的抑制剂，对小鼠sEH和人sEH的IC50值分别为18 nM和69 nM。AUDA具有抗炎活性，可降低MMP-9、IL-1β、TNF-α 和 TGF-β。AUDA还可下调 Smad3 和 p38 信号通路。 AUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC|50|= 18 nM in mice). AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. At a concentration of 10 μM, AUDA is able to activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ.
