β-雌二醇17-（β-D-葡萄糖醛酸）钠盐是在肝脏中形成的并在胆汁中排泄的糖皮质激素雌激素代谢产物。β-雌二醇17-（β-D-葡糖醛酸）钠盐可作为多药抗性蛋白2（MRP2）的底物，而β-雌二醇17-（β-D-葡糖醛酸）钠盐实际上可以减少胆汁流量。与MRP2位点结合后，β-雌二醇17-（β-D-葡糖醛酸）钠盐已显示出结合变构位点，该变构位点通过MRP2激活其自身的转运，并激活其他MRP2底物的转运，包括非胆固醇雌激素代谢产物。还已经观察到β-雌二醇17-（β-D-葡糖醛酸苷）钠盐被MDR1，MRP1，MRP β-Estradiol 17-(β-D-glucuronide) sodium salt is a glucocorticosteroid estrogen metabolite formed in the liver, and excreted in bile. β-Estradiol 17-(β-D-glucuronide) sodium salt functions as a substrate of the multidrug resistance protein 2 (MRP2), and with its cholestatic agentry, β-Estradiol 17-(β-D-glucuronide) sodium salt can actually decrease bile flow. After binding to the MRP2 site, β-Estradiol 17-(β-D-glucuronide) sodium salt has been shown to bind to an allosteric site that activates its own transport via MRP2, and the transport of other MRP2 substrates including non-cholestatic estrogen metabolites. β-Estradiol 17-(β-D-glucuronide) sodium salt has also been observed being transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2, and rat organic anion-transporting polypeptides 1-4.
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β-Estradiol 17-(β-D-glucuronide) sodium salt
Dangerous GoodsCAS number：15087-02-2 molecular formula：C24H31O8·Na[XH2O]
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | PD018024 | sodium 17beta-estradiol 17-glucosiduronate | Estradiol 17-(-D-Glucuronide) (sodium) | Q27156498 | CHEBI:82962 | HY-129987 | beta-D-Glucopyranosiduronic acid, (17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl, sodium salt (1:1) | sodium (17beta)-3-h | ||
| CAS number | 15087-02-2 | molecular formula | C24H31O8·Na[XH2O] |
| molecular weight | 470.5(anhydrous) g/m | Exact mass | ≥95% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS07
Signal word：
Warning
Hazard Statement：
H351: 怀疑引起遗传缺陷 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣
WGK Germany：
3
Personal protective equipment：
Eyeshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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