说明： Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 Information Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells. Targets SREBP In vitro Fatostatin impairs the activation process of sterol regulatory element binding proteins (SREBPs), thereby decreasing the transcription of lipogenic genes in cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain. In vivo Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin may serve as a tool for gaining further insights into the regulation of SREBP. Cell Research(from reference) Cell lines：CHO-K1 cells Concentrations：20 μM Incubation Time：20 h
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Fatostatin
Dangerous GoodsCAS number：125256-00-0 molecular formula：C18H18N2S
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| Chinese alias | 4-[4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶 | ||
| English alias | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole | Fatostatin;125B11 | BCP20994 | cid_2850562 | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | 4-(4-METHYLPHENYL)-2-(2-PROPYL-4-PYRIDYL)-1,3-TH | ||
| CAS number | 125256-00-0 | molecular formula | C18H18N2S |
| molecular weight | 294.41 g/mol | Exact mass | ≥98% |
| PSA | 54.000 Ų | logp | 4.898 |
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pictogram：
GHS06
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Danger
Hazard Statement：
H301: 吞咽会中毒 H413: 可能对水生生物造成长期的有害影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
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