25,26-Dihydroxyvitamin D3

Dangerous Goods

CAS number：29261-12-9 molecular formula：C27H44O3

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The \bone calcium mobilization\ of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3. Form:Solid IC50& Target:Human Endogenous Metabolite

Specs

Chinese alias	25,26-二羟基维生素 D3
English alias	(6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-1,2-diol \| AKOS030526771 \| 9,10-Secocholesta-5,7,10(19)-triene-3,25,26-triol, (3beta,5Z,7E)- \| 25,26
CAS number	29261-12-9	molecular formula	C27H44O3
molecular weight	416.64 g/mol	Exact mass	≥98%
PSA	60.700 Å²	logp	5.1

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Safety information

pictogram：

GHS06 , GHS08

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H311: 皮肤接触有毒 H330: 吸入致命 H372: 通过长时间或反复暴露对器官造成损害 H301+H311: 吞咽或皮肤接触可致中毒。

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持