Melagatran是一种通过防止人血小板-单核细胞异型复合物中组织因子表达而发挥作用的药物。研究表明，Melagatran在PRP血凝块模型中引起纤维蛋白溶解活性，这与在贫血的组织因子诱导的血凝块模型中观察到的结果相当。此外，这些研究还确定了Melagatran的纤维蛋白溶解能力不受血小板存在的影响。Melagatran以剂量依赖的方式影响血小板凝集，低浓度的血小板具有更大的功效。还已经提出，与α-凝血酶/ PAR-1受体相比，Melagatran可以差异地抑制γ-凝血酶/ PAR-4受体。 Melagatran is an agent which functions by preventing tissue factor expression in human platelet-monocyte heterotypic complexes. Studies indicate that Melagatran causes fibrinolytic activity in PRP clot models, which is comparable to that observed in platelet-poor models which consist of tissue factor-induced clots. In addition, these studies determined that the fibrinolysis ability of Melagatran is not affected by the presence of platelets. Melagatran effects platelet aggregation in a dose dependent manner, with low concentration having the greater effectiveness. Also it has been suggested that Melagatran can differentially inhibit γ-thrombin/PAR-4 receptors over α-thrombin/PAR-1 receptors.
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Melagatran
Dangerous GoodsCAS number：159776-70-2 molecular formula：C22H31N5O4
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | 159776-70-2 (free base) | Q27084209 | ((R)-2-((S)-2-((4-carbamimidoylbenzyl)carbamoyl)azetidin-1-yl)-1-cyclohexyl-2-oxoethyl)glycine | BBL000591 | N-((R)-(((2S)-2-((p-Amidinobenzyl)carbamoyl)-1-azetidinyl)carbonyl)cyclohexylmethyl)glycine | SMR000272989 | | ||
| CAS number | 159776-70-2 | molecular formula | C22H31N5O4 |
| molecular weight | 429.51 g/mol | Exact mass | - |
| PSA | 149.000 Ų | logp | -1.000 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
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