Methotrexate-methyl-d3

Dangerous Goods

CAS number：432545-63-6 molecular formula：C20H19D3N8O5

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

甲氨蝶呤-甲基-d3是氘化形式的甲氨蝶呤，一种抗肿瘤药和抗风湿药。研究表明，甲氨蝶呤-甲基-d3可以作为叶酸拮抗剂。甲氨蝶呤竞争性且不可逆地抑制四氢叶酸合成中必不可少的二氢叶酸还原酶（DHFR）。另外，四氢叶酸合成的减少引起嘌呤碱基合成的减少，这导致DNA，RNA，胸苷酸和蛋白质的抑制。替代研究表明，甲氨蝶呤-甲基-d3可通过抑制IL-1抑制T细胞活化和粘附分子表达。 Methotrexate-methyl-d3 is a deuterated form of methotrexate, an antineoplastic and antirheumatic agent. Studies indicate that methotrexate-methyl-d3 can act as a folic acid antagonist. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression.

Specs

Chinese alias	-
English alias	Amethopterin-d3 \| MTX-d3 \| (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl-d3)amino)benzoyl)-L-glutamic acid
CAS number	432545-63-6	molecular formula	C20H19D3N8O5
molecular weight	457.46 g/mol	Exact mass	≥98 atom% D,≥98%
PSA	211.000 Å²	logp	-1.8

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS06 , GHS08 , GHS07

Signal word：

Danger

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H301: 吞咽会中毒 H360: 可能损害生育力或未出生的孩子 H340: 可能导致遗传缺陷

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P281: 根据需要使用个人防护设备。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P362+P364: 脱掉沾污的衣服，清洗后方可