粉蝶霉素A是一种抗生素，也是I类抑制剂的成员。Piericidin A可以有效抑制I型细菌和线粒体NADH-泛醌氧化还原酶（复合物I）。作为NADH脱氢酶的抑制剂，Piericidin A抑制电子转移。研究表明，Piericidin A阻止NADH内源性泛醌还原酶反应中NADH诱导的质子的移位，并且Piericidin A在复合物I的NUOD-NUOB界面附近结合。PiericidinA也被称为AR-054，Shaoguanmycin B ，抗生素MT 1882-I，SN 198E和2-[（（2E，5E， Piericidin A is an antibiotic and a member of the Class I inhibitors. Piericidin A acts as an effective inhibitor of the bacterial and mitochondrial type I NADH-ubiquinone oxidoreductases (Complex I). As an inhibitor of NADH dehydrogenase, Piericidin A inhibits electron transfer. Research indicates that Piericidin A prevents the translocation of the NADH-induced proton in the NADH-endogenous ubiquinone reductase reaction, and that Piericidin A binds near the NUOD-NUOB interface of Complex I. Piericidin A is also known as AR-054, Shaoguanmycin B, Antibiotic MT 1882-I, SN 198E, and 2-[(2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4(1H)-pyridinone.
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Piericidin A
Dangerous GoodsCAS number：2738-64-9 molecular formula：C25H37NO4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | BRD-K73581776-001-01-6 | NCGC00180489-01 | Q7191888 | AKOS040746399 | Piericidine A | SCHEMBL18941698 | 2,6,9,11-Tridecatetraen-4-ol, 13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-, (all-E)-(4R,5R)- | 2-[(2E,5E,7E,11E)-10R-hydroxy-3 | ||
| CAS number | 2738-64-9 | molecular formula | C25H37NO4 |
| molecular weight | 415.57 g/mol | Exact mass | ≥95% |
| PSA | 67.800 Ų | logp | 6.1 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持
WGK Germany：
1
Personal protective equipment：
Eyeshields， Faceshields， full-face respirator (US)， Gloves， multi-purpose combination respirator cartridge (US)， type ABEK (EN14387) respirator filter
RTECS：
YD4588000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
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