Mitomycin C (Ametycine) 是一种 DNA 交联剂 (DNA cross-linking agent)，诱导 DNA 损伤。Mitomycin C 是一种抗肿瘤化合物和抗生素，可有效的抑制 DNA 合成 (DNA synthesis)。Mitomycin C 是一种 ADC 毒性分子 (ADC Cytotoxin)，可以诱导凋亡 (Apoptosis) 作用。 Information Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner. In vitro Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. In vivo As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥97%
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Mitomycin C
Dangerous GoodsCAS number：50-07-7(DMSO) molecular formula：C15H18N4O5
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| Chinese alias | 丝裂霉素 | 密吐霉素 | 自力霉素 | 突变霉素 | ||
| English alias | KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri | ||
| CAS number | 50-07-7(DMSO) | molecular formula | C15H18N4O5 |
| molecular weight | 334.37 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | -1.547 |
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