compound introduction
VcMMAE (mc-vc-PAB-MMAE)，一种具有缬氨酸-瓜氨酸(Vc)接头的MMAE衍生物，是具有抗肿瘤活性的antibody-drug conjugate (ADC)。MMAE是一种合成的抗肿瘤药，在体外可以有效地从VcMMAE释放出来并发挥细胞毒活性。
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VcMMAE
Dangerous GoodsCAS number：646502-53-6 molecular formula：C68H105N11O15
overview
Specs
| Chinese alias | - | ||
| English alias | A14362 | Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E | s6661 | VEDOTIN PARENT | MFCD25372036 | MC-Val-Cit-PAB-MMAE | VcMMAE | Vc-MMAE | AKOS037643764 | 026S2O80A8 | AC-32509 | MC-vc-PAB-MMAE | Q27231498 | UNII-026S2O | ||
| CAS number | 646502-53-6 | molecular formula | C68H105N11O15 |
| molecular weight | 1316.63 g/mol | Exact mass | ≥98% |
| PSA | 347.000 Ų | logp | 4.9 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命 H300+H310+H330: 吞咽，皮肤接触或吸入会致命。
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请
Production methods and uses
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MSDS
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