Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1 Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1 A protein synthesis-inhibiting antibiotic
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Thiostrepton
Dangerous GoodsCAS number：1393-48-2 molecular formula：C72H85N19O18S5
overview
compound introduction
Specs
| Chinese alias | 硫链丝菌素 | ||
| English alias | thiostrepton | Thiactin | Bryamycin | 1393-48-2 | Thiostrepton from Streptomyces azureus | Alaninamide, | NSC81722 | NSC 81722 | NSC170365 | NSC 170365 | CHEMBL1981887 | CHEBI:94340 | AKOS040742575 | NCGC00485235-01 | Thiostrepton from Streptomyces azureu | ||
| CAS number | 1393-48-2 | molecular formula | C72H85N19O18S5 |
| molecular weight | 1664.89 g/mol | Exact mass | 10mM in DMSO |
| PSA | 701.000 Ų | logp | 0.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
XN6300100
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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