Questiomycin A是由几种链霉菌以及一些真菌和细菌产生的吩恶嗪。Questiomycin A对细菌，真菌，植物和肿瘤细胞系具有弱活性，并抑制芳香酶和硫酸酯酶。Questiomycin与其他phenoxazines一样，在体外刺激细胞生长和更新，其活性可能与其形成稳定自由基的能力有关。最近，已显示出Questiomycin A抑制由小鼠黑素瘤细胞引起的肺转移。Questiomycin A和相关的吩恶嗪是发现研究中重要的重复复制标准，用于消除由于大量弱效活性物质而导致的铅。 Questiomycin A is a phenoxazine produced by several|Streptomyces|species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumour cell lines, and inhibits aromatase and sulfatases. Questiomycin, like other phenoxazines, stimulates cell growth and turnover|in vitro|, an activity possibly related to their ability to form stable free radicals. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.
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Questiomycin A
Dangerous GoodsCAS number：1916-59-2 molecular formula：C12H8N2O2
overview
compound introduction
Specs
| Chinese alias | 奎霉素A | 寻霉素 A | 2-氨基-3H-吩恶嗪-3-酮 | ||
| English alias | DTXSID60172691 | 2-acetylamino-(3h)-phenoxazin-3-one | 2-aminophenoxazine-3-one | 3H-Phenoxazin-3-one,2-amino- | Acrospermumviticola toxin C | Dibenzo(b,h)pyrene | BRN 0014215 | F11662 | NCIOpen2_006212 | 3-Aminophenoxazone | J-012388 | METHYLENECYCLOHEXA | ||
| CAS number | 1916-59-2 | molecular formula | C12H8N2O2 |
| molecular weight | 212.20 g/mol | Exact mass | - |
| PSA | 64.700 Ų | logp | 1 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
RTECS：
SP76950000
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
