Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations sμggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats sμggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.A cell permeable inhibitor of ROCK-1 and ROCK-2 Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2. A cell permeable inhibitor of ROCK-1 and ROCK-2
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Y-27632 dihydrochloride
Dangerous GoodsCAS number：129830-38-2 molecular formula：C14H21N3O·2HCl
overview
compound introduction
Specs
| Chinese alias | (1R,4r)-4-[(R)-1-氨乙基]-N-(吡啶-4-基)环己烷甲酰胺二盐酸盐 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)环己烷甲酰胺 二盐酸盐 | ||
| English alias | ROCK Inhibitor | CYCLOHEXANECARBOXAMIDE, 4-((1R)-1-AMINOETHYL)-N-4-PYRIDINYL-, HYDROCHLORIDE (1:2), TRANS- | DTXSID90204535 | Y-27632 - CAS 146986-50-7 | HY-10583 | DTXSID3042635 | Unibiotic | NCGC00261018-01 | (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL) | ||
| CAS number | 129830-38-2 | molecular formula | C14H21N3O·2HCl |
| molecular weight | 320.26 g/mol | Exact mass | ≥98% |
| PSA | 68.000 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 H302+H312+H332: 吞咽，皮肤接触或吸入有害。
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US), Eyeshields, Gloves
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
