CAS number：497839-62-0 molecular formula：C27H32N6
AEE788(NVP-AEE 788)是高活性的EGFR和HER2/ErbB2抑制剂，IC50分别为2 nM和6 nM，对VEGFR2/KDR，c-Abl，c-Src和Flt-1抑制性较弱，对Ins-R，IGF-1R, PKCα and CDK1无抑制性。 AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1.
| Chinese alias | - | ||
| English alias | 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[3,2-e]pyrimidin-4-amine | 7,9-Dimethyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline | AKOS016011091 | HMS1681K22 | AEE 788 [WHO-DD] | DB12558 | GTPL7643 | SW219869-1 | | ||
| CAS number | 497839-62-0 | molecular formula | C27H32N6 |
| molecular weight | 440.58 g/mol | Exact mass | ≥97% |
| PSA | 60.100 Ų | logp | 4.6 |
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