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LDN-57444

Dangerous Goods

CAS number：668467-91-2    molecular formula：C17H11Cl3N2O3

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overview

compound introduction

LDN-57444是一种可逆的竞争性的蛋白酶体抑制剂，，抑制UCch-L1时，IC50为0.88 μM，比作用于亚型Uch-L3选择性高30倍。 LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. A potent, reversible, active site-directed UCH-L1 inhibitor

Specs

Chinese alias-
English aliasHY-18637 | SW219408-1 | UCH-L1 | [(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate | LDN 57444 | SCHEMBL16249746 | 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) | LDN-57444, >=98% (HPLC) | BD
CAS number668467-91-2molecular formulaC17H11Cl3N2O3
molecular weight397.64 g/molExact mass10mM in DMSO
PSA59.000 Ųlogp4.600

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS09
Signal word：
Warning
Hazard Statement：
H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
WGK Germany：
3

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