compound introduction
NSC348884是一种核仁磷蛋白，在核糖体的生物发生，细胞增殖，细胞质/核穿梭运输，核酸结合，核糖核酸裂解和中心体复制中显示出多种生物学活性。NSC 348884是推定的核磷蛋白（核仁磷蛋白B23）抑制剂。NSC 348884抑制NPM低聚物形成，上调p53并诱导凋亡。 NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (nucleolar phosphoprotein B23). NSC 348884 inhibits NPM oligomer formation, up-regulates p53 and induces apoptosis.
