compound introduction
隐陡头菌素S 是有效的抗肿瘤倍半萜烯，1963年首次从真菌| Clitocybe illudens |中分离出来。隐陡头菌素S 被代谢活化为结合DNA的反应性中间体。DNA损伤似乎与其他反应性代谢产物不同。重要的是，隐陡头菌素S 对多种药物耐药的肿瘤表现出体外和体内效力。 Illudin S is potent antitumor sesquiterpene, first isolated from the fungus,|Clitocybe illudens|, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
