Information Itanapraced (CHF 5074) Itanapraced (CHF 5074, CSP-1103) is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L. Targets γ secretase In vitro In human neuroglioma cells over-expressing the Swedish mutated APP [human neuroglioma cell line expressing APPswe (H4swe)], CHF5074 preferentially lowers Aβ42 secretion with an IC50 of 3.6 µmol/L. CHF5074 does not display inhibitory activity on COX-1 and COX-2 enzymes when employed at concentrations up to 100 µmol/L and 300 µmol/L respectively. In vivo In rats, CHF5074 is orally well absorbed (50%) and is slowly eliminated from plasma (t1/2 ≈ 20 h). In Tg2576 transgenic mice, chronic treatment with CHF5074 markedly reduces brain Aβ burden without histological signs of peripheral Notch-mediated toxicity.
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Itanapraced (CHF 5074)
Dangerous GoodsCAS number：749269-83-8 molecular formula：C16H11Cl2FO2
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compound introduction
Specs
| Chinese alias | 伊塔那普拉塞德 (5074 瑞士法郎) | ||
| English alias | CSP1103 | CSP-1103 | GTPL7339 | SB16945 | 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid | NCGC00408905-01 | HMS3886F13 | 1-(3',4'-Dichloro-2-Fluorobiphenyl-4-Yl)cyclopropanecarboxylic Acid | UNII-C35RF1MWQZ | ITANAPRACED [WHO | ||
| CAS number | 749269-83-8 | molecular formula | C16H11Cl2FO2 |
| molecular weight | 325.16 g/mol | Exact mass | - |
| PSA | 37.300 Ų | logp | 4.700 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H320: 引起眼睛刺激
Statement of Preventive Measures：
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。
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