compound introduction
Information NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. Targets p53 In vitro NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells. In vivo In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. Cell Research(from reference) Cell lines：SW480, DLD-1, HCT116, p53- HCT116, MRC5, Hop92, RXF393 and Wi38 cells Concentrations：~100 μM Incubation Time：72 h
