Information Selonsertib (GS-4997) Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Targets ASK1 (Cell-free assay) 8.3(pIC50) In vivo An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Upon oral administration, ASK1 inhibitor GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. This prevents the phosphorylation of downstream kinases, such as c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK). By preventing the activation of ASK1-dependent signal transduction pathways, GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
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Selonsertib (GS-4997)
Dangerous GoodsCAS number：1448428-04-3 molecular formula：C24H24FN7O
overview
compound introduction
Specs
| Chinese alias | 司隆色替 | 瑟隆舍替 | 塞隆塞替尼 (GS-4997) | ||
| English alias | AMY27913 | HY-18938 | 1448428-04-3 | (2S,SR)-METHIONINE SULFOXIMINE | EX-A1618 | GS 4997 | Selonsertib (GS-4997) | UNII-NS3988A2TC | AC-31493 | Selonsertib [USAN:INN] | Selonsertib; GS-4997 | SB17466 | DB14916 | EX-A1150 | Q27088777 | AKOS027338646 | SELO | ||
| CAS number | 1448428-04-3 | molecular formula | C24H24FN7O |
| molecular weight | 445.49 g/mol | Exact mass | - |
| PSA | 90.500 Ų | logp | 4.054 |
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Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P319: 如果你感到不适，请寻求医疗帮助。
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