Erdafitinib (JNJ-42756493)

Dangerous Goods

CAS number：1346242-81-6 molecular formula：C25H30N6O2

overview

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physicochemical properties

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Production methods and uses

MSDS

overview

compound introduction

Information Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, panfibroblast growth factor receptor (FGFR)inhibitor with potential antineoplastic activity. Erdafitinib also binds toRET (c-RET),CSF-1R,PDGFR-α/PDGFR-β,FLT4,Kit (c-Kit)andVEGFR-2and induces cellularapoptosis. Targets FGFR ; RET ; CSF-1R ; PDGFR ; Kit 16439, In vitro JNJ-42756493 is a potent, oral pan-FGFR tyrosine kinase inhibitor with half-maximal inhibitory concentration values in the low nanomolar range for all members of the FGFR family (FGFR1 to FGFR4), with minimal activity on vascular endothelial growth factor receptor (VEGFR) kinases compared with FGFR kinases (approximately 20-fold potency difference). the proliferation of cells treated with JNJ-42756493 is decreased, associated with increased apoptotic death and decreased cell survival. In vivo growth of NCI-H716 tumors is delayed by 5 days by drug treatment alone, although when drug delivery is stopped the relative tumor volume increased compared to control. JNJ-42756493 shows favorable drug like properties and displays a high distribution to lung, liver and kidney tissue. JNJ-42756493 is well tolerated at efficacious doses and results in potent dose-dependent antitumor activity accompanied by pharmacodynamic modulation of tumor FGFR and downstream pathway components. Cell Research(from reference) Cell lines：HCT116, HCA7, Caco2 and NCI-H716 cells Incubation Time：72 h

Specs

Chinese alias	-
English alias	AS-35040 \| Erdafitinib(JNJ-42756493) \| NCGC00475735-01 \| BCP20346 \| DTXSID001027936 \| ERDAFITINIB [WHO-DD] \| JNJ 42756493 \| N'-(3,5-dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine \| Balversa (TN) \| F0001-1665
CAS number	1346242-81-6	molecular formula	C25H30N6O2
molecular weight	446.54 g/mol	Exact mass	-
PSA	77.300 Å²	logp	3.943

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Safety information

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GHS08 , GHS05 , GHS07

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Danger

Hazard Statement：

H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H372: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P333+P313