BG45

Dangerous Goods

CAS number：926259-99-6 molecular formula：C11H10N4O

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information BG45 is a class IHDACinhibitor withIC50of 289 nM, 2.0 µM, 2.2 µM and >20 µM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively. Targets HDAC3 ; HDAC1 ; HDAC2 289 nM; 2 μM; 2.2 μM In vitro BG45 causes significant cell growth inhibition and induces caspase-dependent apoptosis in a series of MM cells. In RPMI8226 cells, BG45 synergistically enhances bortezomib-induced cytotoxicity. In vivo In mice bearing MM.1S xenograft of human MM, BG45 (50 mg/kg, i.p.) significantly inhibits MM tumor growth. When in combination with bortezomib, BG45 (50 mg/kg, i.p.) enhances bortezomib-induced cytotoxicity. Cell Research(from reference) Cell lines：MM.1S, RPMI8226, U266, H929, MM.1\u2009R, RPMI-LR5, OPM1, OPM2 and RPMI-DOX40 cells Concentrations：~30 μM Incubation Time：48 h

Specs

Chinese alias	-
English alias	SCHEMBL18064956 \| BRD-K27756844-001-02-7 \| ethyl 3-(4-fluorophenyl)-3-oxopropanoate;BG45 \| NaOtert-Bu \| NCGC00261313-01 \| FT-0660584 \| BDBM50470567 \| CCG-266677 \| BCP15990 \| LMWPVSNHKACEKW-UHFFFAOYSA-N \| BMB25999 \| NCGC00402247-01 \| A856607 \| AKOS00243452
CAS number	926259-99-6	molecular formula	C11H10N4O
molecular weight	214.22 g/mol	Exact mass	≥97%
PSA	80.900 Å²	logp	0.300

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移