CAS number：919091-63-7 molecular formula：C19H15N3O5
说明： RA-9 是一种高效选择性蛋白酶体相关 DUBs 抑制剂，具有良好的毒性和抗癌活性。RA-9 阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。RA-9 选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。RA-9 诱导卵巢癌细胞内质网应激反应。 Information RA-9 RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. Targets DUBs
| Chinese alias | - | ||
| English alias | (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]piperidin-4-one | YUYPWAMLWZVHAE-KAVGSWPWSA-N | 3,5-bis(4-nitrobenzylidene)piperidin-4-one | SCHEMBL14797847 | (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one | HY-136528 | RA-9, >=98% (HPLC) | (3E,5E)-3 | ||
| CAS number | 919091-63-7 | molecular formula | C19H15N3O5 |
| molecular weight | 365.34 g/mol | Exact mass | ≥98% |
| PSA | 121.000 Ų | logp | 2.800 |
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