CAS number：1187431-43-1 molecular formula：C28H29FIN5O5S
Information Trametinib (GSK1120212, JTP-74057, Mekinist) DMSO solvate is a highly specific and potentMEK1/2inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activatesautophagyand inducesapoptosis. Targets MEK1 (Cell-free assay); MEK2 (Cell-free assay) 0.92 nM; 1.8 nM
| Chinese alias | - | ||
| English alias | JTP-74057 (DMSO solvate) | AS-17069 | GSK-1120212 (DMSO solvate) | 1187431-43-1 | N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfin | ||
| CAS number | 1187431-43-1 | molecular formula | C28H29FIN5O5S |
| molecular weight | 693.53 g/mol | Exact mass | ≥99% |
| PSA | 138.000 Ų | logp | 2.86 |
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