UMI-77

Dangerous Goods

CAS number：518303-20-3 molecular formula：C18H14BrNO5S2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information UMI-77 UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Targets Mcl-1 (Cell-free assay) 490 nM(Ki) In vitro UMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change. In vivo In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg i.v.) exhibits single-agent antitumor activity without any damage normal tissues. Cell Research(from reference) Cell lines：Human pancreatic cancer cell lines AsPC-1, BxPC-3, Panc-1, MiaPaCa and Capan-2 Concentrations：~100 μM Incubation Time：4 days

Specs

Chinese alias	-
English alias	2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid \| UMI 77
CAS number	518303-20-3	molecular formula	C18H14BrNO5S2
molecular weight	468.34 g/mol	Exact mass	-
PSA	137.000 Å²	logp	3.755

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS05 , GHS07

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Danger

Hazard Statement：

H315: 引起皮肤刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H318: 造成严重的眼睛损伤

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口 P304+P340+P312: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。