TN-16是一种合成的抗肿瘤药物,可通过与微管蛋白的秋水仙碱位点结合来阻止微管组装。TN-16阻止紫杉醇处理的细胞中微管的稳定。该化合物还阻断了M期的细胞周期。 TN-16 is a synthetic antitumor drug that blocks microtubule assembly by binding to the colchicine site of Tubulin. TN-16 prevents stabilization of microtubules in Paclitaxel-treated cells. The compound also blocks the cell cycle in M phase.
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TN-16
Dangerous GoodsCAS number:33016-12-5 molecular formula:C19H18N2O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | NSC100445 | NSC-100445 | SCHEMBL6739845 | SMR001570259 | tn-16 | (3Z)-3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione | HY-119357 | (3Z)-3-(1-anilinoethylidene)-5-benzyl-pyrrolidine-2,4-quinone | AC-35569 | Benzenepropanoic acid, 3-((dimethylaminome | ||
| CAS number | 33016-12-5 | molecular formula | C19H18N2O2 |
| molecular weight | 306.36 g/mol | Exact mass | ≥98% |
| PSA | 61.700 Ų | logp | 2.7 |
numbering system
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physicochemical properties
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Safety information
pictogram:
GHS09 , GHS07
Signal word:
Warning
Hazard Statement:
H317: 可能引起皮肤过敏反应 H400: 对水生生物有剧毒
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P391: 收集溢出物
WGK Germany:
3
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MSDS
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